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KMID : 1138520060090010033
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Journal of Pharmacopuncture
2006 Volume.9 No. 1 p.33 ~ p.44
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Effects of Sedang-hwan on Experimental Diabetic Rats induced by Streptozotocin
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Bae Chul-Ho
Soh Kyung-Soon
Jeong Chan-Gil
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Abstract
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Objectives : We performed this study in order to investigate the effects of Sedang-hwan(世糖丸) on the diabetes mellitus.
Methods : We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-hwan; 18.7mg/kg/day to sample groups and observed the weight and glucose level, insulin, C-peptide, triglyceride, albumin, T-protein, BUN(Blood Urea Nitrogen) and creatinine in blood.
Results : 1. The sample groups showed a high suppressive effect of weight loss(P=0.002). 2. The sample groups’’ glucose level showed a effective in lowering level(P=0.001). 3. The sample groups showed a higher insulin level than control groups. 4. The sample groups showed a higher C-peptide level than control groups(P=0.001). 5. The sample groups’’ triglyceride level showed a effective in lowering level. 6. The sample groups showed a higher HDL-cholesterol level than control groups(P<0.001). 7. The sample groups showed a higher T-protein level than control groups(P=0.04). 8. The sample groups showed a higher albumin level than control groups(P<0.001). 9. The sample groups’’ creatinine level showed a effective in lowering level(P=0.04). 10. The sample groups’’ BUN level showed a effective in lowering level(P=0.03).
Conclusions : Conclusively, Sedang-hwan was recognized to have decrease effect of serum glucose, triglyceride, creatinine, BUN of the diabetic rats induced by streptozotocin. It was suggested that Sedang-hwan can be used for effective diabetes mellitus medical treatment. It is also required to study further about detailed principles of blood-sugar dropping effect by Sedang-hwan, and recovery by diabetes mellitus.
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KEYWORD
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Sedang-hwan, Streptozotocin, Rats, Diabetes Mellitus
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